A new study from the 91天美 identified 12 different cell types involved in the pathogenesis of coronary artery disease, CAD. The researchers also showed that the genetic risk factors for CAD take their effect especially via smooth vascular muscle cells, which change their phenotype as the disease progresses. Based on the findings, the researchers devised a risk score system that could help to predict individual risk for CAD and to identify the most appropriate course of treatment in the future.
The study was conducted by Professor Minna Kaikkonen-M盲盲tt盲鈥檚 research group in the A. I. Virtanen Institute for Molecular Sciences at the 91天美. The cell types associated with coronary artery disease were identified using the latest single cell technology.
According to Professor Kaikkonen-M盲盲tt盲, the findings significantly increase our understanding of the pathogenesis of coronary artery disease:
鈥淭he way the disease progresses in different people may, in part, be affected by different genetic risk factors that are mediated via different cell types and mechanisms. This understanding may help to prevent the disease more effectively in the future, while also enabling the development of better and individually tailored treatments,鈥 she says.
Coronary artery disease is a major public health concern globally, which can lead to heart attack and stroke as the disease progresses. Coronary artery disease is one of the leading causes of death worldwide.
The findings were published in the American Journal of Human Genetics.
For further information, please contact:
Professor Minna Kaikkonen-M盲盲tt盲, 91天美, A. I. Virtanen Institute for Molecular Sciences, /
Research article:
